The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
Identifieur interne : 007B53 ( Main/Exploration ); précédent : 007B52; suivant : 007B54The TP53 Arg72Pro and MDM2 309G>T polymorphisms are not associated with breast cancer risk in BRCA1 and BRCA2 mutation carriers
Auteurs : O M Sinilnikova [France] ; A C Antoniou [Royaume-Uni] ; J. Simard [Canada] ; S. Healey [Australie] ; M. Léoné [France] ; D. Sinnett [Canada] ; A B Spurdle [Australie] ; J. Beesley [Australie] ; X. Chen [Australie] ; M H Greene [États-Unis] ; J T Loud [États-Unis] ; F. Lejbkowicz [Israël] ; G. Rennert [Israël] ; S. Dishon [Israël] ; I L Andrulis [Canada] ; S M Domchek [États-Unis] ; K L Nathanson [États-Unis] ; S. Manoukian [Italie] ; P. Radice [Italie] ; I. Konstantopoulou [Grèce] ; I. Blanco [Espagne] ; A L Laborde [Espagne] ; M. Durán [Espagne] ; A. Osorio [Espagne] ; J. Benitez [Espagne] ; U. Hamann [Allemagne] ; F B L. Hogervorst [Pays-Bas] ; T A M. Van Os [Pays-Bas] ; H J P. Gille [Pays-Bas] ; S. Peock [Royaume-Uni] ; M. Cook [Royaume-Uni] ; C. Luccarini [Royaume-Uni] ; D G Evans [Royaume-Uni] ; F. Lalloo [Royaume-Uni] ; R. Eeles [Royaume-Uni] ; G. Pichert [Royaume-Uni] ; R. Davidson [Royaume-Uni] ; T. Cole [Royaume-Uni] ; J. Cook [Royaume-Uni] ; J. Paterson [Royaume-Uni] ; C. Brewer [Royaume-Uni] ; D J Hughes [Irlande (pays)] ; I. Coupier [France] ; S. Giraud [France] ; F. Coulet [France] ; C. Colas [France] ; F. Soubrier [France] ; E. Rouleau [France] ; I. Bièche [France] ; R. Lidereau [France] ; L. Demange [France] ; C. Nogues [France] ; H T Lynch [États-Unis] ; R K Schmutzler [Allemagne] ; B. Versmold [Allemagne] ; C. Engel [Allemagne] ; A. Meindl [Allemagne] ; N. Arnold [Allemagne] ; C. Sutter [Allemagne] ; H. Deissler [Allemagne] ; D. Schaefer [Allemagne] ; U G Froster [Allemagne] ; K. Aittom Ki [Finlande] ; H. Nevanlinna [Finlande] ; L. Mcguffog [Royaume-Uni] ; D F Easton [Royaume-Uni] ; G. Chenevix-Trench [Australie] ; D. Stoppa-Lyonnet [France]Source :
- British Journal of Cancer [ 0007-0920 ] ; 2009.
Abstract
The
To investigate whether these SNPs modify breast cancer risk for
No association was found between these SNPs and breast cancer risk for
There was no evidence that
Url:
DOI: 10.1038/sj.bjc.6605279
PubMed: 19707196
PubMed Central: 2768437
Affiliations:
- Allemagne, Australie, Canada, Espagne, Finlande, France, Grèce, Irlande (pays), Israël, Italie, Pays-Bas, Royaume-Uni, États-Unis
Links toward previous steps (curation, corpus...)
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- to stream Pmc, to step Checkpoint: 002716
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- to stream Ncbi, to step Checkpoint: 000635
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- to stream Main, to step Curation: 007B53
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The <italic>TP53</italic> Arg72Pro and <italic>MDM2</italic> 309G>T polymorphisms are not associated with breast cancer risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers</title><author><name sortKey="Sinilnikova, O M" sort="Sinilnikova, O M" uniqKey="Sinilnikova O" first="O M" last="Sinilnikova">O M Sinilnikova</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon / Centre Léon Bérard</institution> Lyon 69373,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Laboratoire de Génétique Moléculaire, Signalisation et Cancer, UMR5201 CNRS, Université de Lyon</institution> Lyon 69373,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Antoniou, A C" sort="Antoniou, A C" uniqKey="Antoniou A" first="A C" last="Antoniou">A C Antoniou</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</institution> Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simard, J" sort="Simard, J" uniqKey="Simard J" first="J" last="Simard">J. Simard</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec and Laval University</institution> Quebec,<country>Canada</country> G1V 4G2</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Healey, S" sort="Healey, S" uniqKey="Healey S" first="S" last="Healey">S. Healey</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Queensland Institute of Medical Research</institution> Brisbane QLD 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Leone, M" sort="Leone, M" uniqKey="Leone M" first="M" last="Léoné">M. Léoné</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon / Centre Léon Bérard</institution> Lyon 69373,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sinnett, D" sort="Sinnett, D" uniqKey="Sinnett D" first="D" last="Sinnett">D. Sinnett</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Division of Hematology-Oncology, Research Center, CHU Sainte-Justine</institution> Montreal,<country>Canada</country> H3T 1C5</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Pediatrics, University of Montreal</institution> Montreal,<country>Canada</country> H3T 1C5</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spurdle, A B" sort="Spurdle, A B" uniqKey="Spurdle A" first="A B" last="Spurdle">A B Spurdle</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Queensland Institute of Medical Research</institution> Brisbane QLD 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beesley, J" sort="Beesley, J" uniqKey="Beesley J" first="J" last="Beesley">J. Beesley</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Queensland Institute of Medical Research</institution> Brisbane QLD 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, X" sort="Chen, X" uniqKey="Chen X" first="X" last="Chen">X. Chen</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Queensland Institute of Medical Research</institution> Brisbane QLD 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Greene, M H" sort="Greene, M H" uniqKey="Greene M" first="M H" last="Greene">M H Greene</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution> Rockville, MD 20852-7231,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Loud, J T" sort="Loud, J T" uniqKey="Loud J" first="J T" last="Loud">J T Loud</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution> Rockville, MD 20852-7231,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lejbkowicz, F" sort="Lejbkowicz, F" uniqKey="Lejbkowicz F" first="F" last="Lejbkowicz">F. Lejbkowicz</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and Technion Faculty of Medicine</institution> Haifa 34362,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rennert, G" sort="Rennert, G" uniqKey="Rennert G" first="G" last="Rennert">G. Rennert</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and Technion Faculty of Medicine</institution> Haifa 34362,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dishon, S" sort="Dishon, S" uniqKey="Dishon S" first="S" last="Dishon">S. Dishon</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and Technion Faculty of Medicine</institution> Haifa 34362,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Andrulis, I L" sort="Andrulis, I L" uniqKey="Andrulis I" first="I L" last="Andrulis">I L Andrulis</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Ontario Cancer Genetics Network, Cancer Care Ontario, Department of Molecular Genetics, University of Toronto</institution> Toronto, ON,<country>Canada</country> M5G 1X5</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution> Toronto, ON,<country>Canada</country> M5G 1X5</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Domchek, S M" sort="Domchek, S M" uniqKey="Domchek S" first="S M" last="Domchek">S M Domchek</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Department of Medicine, Abramson Cancer Center, University of Pennsylvania School of Medicine</institution> Philadelphia, PA 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nathanson, K L" sort="Nathanson, K L" uniqKey="Nathanson K" first="K L" last="Nathanson">K L Nathanson</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Department of Medicine, Abramson Cancer Center, University of Pennsylvania School of Medicine</institution> Philadelphia, PA 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Manoukian, S" sort="Manoukian, S" uniqKey="Manoukian S" first="S" last="Manoukian">S. Manoukian</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Unit of Medical Genetics, Fondazione IRCCS Istituto Nazionale Tumori</institution> Milano,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Radice, P" sort="Radice, P" uniqKey="Radice P" first="P" last="Radice">P. Radice</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori</institution> Milano 20133,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution> Milano 20139,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Konstantopoulou, I" sort="Konstantopoulou, I" uniqKey="Konstantopoulou I" first="I" last="Konstantopoulou">I. Konstantopoulou</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Molecular Diagnostics Laboratory, IRRP, NCSR ‘Demokritos'</institution> 15310 Ag. Paraskevi, Athens,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blanco, I" sort="Blanco, I" uniqKey="Blanco I" first="I" last="Blanco">I. Blanco</name><affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Cancer Genetic Counseling Program, Institut Català d'Oncologia</institution> Barcelona 08907,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Laborde, A L" sort="Laborde, A L" uniqKey="Laborde A" first="A L" last="Laborde">A L Laborde</name><affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Servicio de Genética, Hospital de la Santa Creu i Sant Pau</institution> Barcelona 08025,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Duran, M" sort="Duran, M" uniqKey="Duran M" first="M" last="Durán">M. Durán</name><affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Laboratorio de Genética del Cáncer, Instituto de Biología y Genética Molecular, Universidad de Valladolid</institution> Valladolid 47002,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Osorio, A" sort="Osorio, A" uniqKey="Osorio A" first="A" last="Osorio">A. Osorio</name><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)</institution> Madrid 28029,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Benitez, J" sort="Benitez, J" uniqKey="Benitez J" first="J" last="Benitez">J. Benitez</name><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)</institution> Madrid 28029,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hamann, U" sort="Hamann, U" uniqKey="Hamann U" first="U" last="Hamann">U. Hamann</name><affiliation wicri:level="1"><nlm:aff id="aff22"><institution>Deutsches Krebsforschungszentrum (DKFZ), Molecular Genetics of Breast Cancer</institution> Heidelberg 69120,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hogervorst, F B L" sort="Hogervorst, F B L" uniqKey="Hogervorst F" first="F B L" last="Hogervorst">F B L. Hogervorst</name><affiliation wicri:level="1"><nlm:aff id="aff23"><institution>Department of Pathology and the Family Cancer Clinic, Netherlands Cancer Institute</institution> Amsterdam 1066 CX,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Os, T A M" sort="Van Os, T A M" uniqKey="Van Os T" first="T A M" last="Van Os">T A M. Van Os</name><affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Department of Clinical Genetics, Amsterdam University Medical Centre</institution> Amsterdam 1105 AZ,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gille, H J P" sort="Gille, H J P" uniqKey="Gille H" first="H J P" last="Gille">H J P. Gille</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Department of Clinical Molecular Genetics, Free University Medical Centre</institution> Amsterdam 1081 HV,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peock, S" sort="Peock, S" uniqKey="Peock S" first="S" last="Peock">S. Peock</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</institution> Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cook, M" sort="Cook, M" uniqKey="Cook M" first="M" last="Cook">M. Cook</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</institution> Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Luccarini, C" sort="Luccarini, C" uniqKey="Luccarini C" first="C" last="Luccarini">C. Luccarini</name><affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Department of Oncology, University of Cambridge</institution> Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Evans, D G" sort="Evans, D G" uniqKey="Evans D" first="D G" last="Evans">D G Evans</name><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust</institution> Manchester M13 OJH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lalloo, F" sort="Lalloo, F" uniqKey="Lalloo F" first="F" last="Lalloo">F. Lalloo</name><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust</institution> Manchester M13 OJH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eeles, R" sort="Eeles, R" uniqKey="Eeles R" first="R" last="Eeles">R. Eeles</name><affiliation wicri:level="1"><nlm:aff id="aff28"><institution>Translational Cancer Genetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust</institution> Sutton, Surrey SM2 5NG,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pichert, G" sort="Pichert, G" uniqKey="Pichert G" first="G" last="Pichert">G. Pichert</name><affiliation wicri:level="1"><nlm:aff id="aff29"><institution>Clinical Genetics, Guy's Hospital</institution> London SE1 9RT,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Davidson, R" sort="Davidson, R" uniqKey="Davidson R" first="R" last="Davidson">R. Davidson</name><affiliation wicri:level="1"><nlm:aff id="aff30"><institution>Ferguson-Smith Centre for Clinical Genetics</institution> Glasgow G3 8SJ,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cole, T" sort="Cole, T" uniqKey="Cole T" first="T" last="Cole">T. Cole</name><affiliation wicri:level="1"><nlm:aff id="aff31"><institution>West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust</institution> Edgbaston, Birmingham B15 2TG,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cook, J" sort="Cook, J" uniqKey="Cook J" first="J" last="Cook">J. Cook</name><affiliation wicri:level="1"><nlm:aff id="aff32"><institution>Sheffield Clinical Genetics Service, Sheffield Children's Hospital</institution> Sheffield S10 2TH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Paterson, J" sort="Paterson, J" uniqKey="Paterson J" first="J" last="Paterson">J. Paterson</name><affiliation wicri:level="1"><nlm:aff id="aff33"><institution>Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital</institution> Cambridge CB2 8QE,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brewer, C" sort="Brewer, C" uniqKey="Brewer C" first="C" last="Brewer">C. Brewer</name><affiliation wicri:level="1"><nlm:aff id="aff34"><institution>Department of Clinical Genetics, Royal Devon & Exeter Hospital</institution> Exeter EX2 5DW,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hughes, D J" sort="Hughes, D J" uniqKey="Hughes D" first="D J" last="Hughes">D J Hughes</name><affiliation wicri:level="1"><nlm:aff id="aff35"><institution>Department of Clinical Medicine, Trinity College Centre for Health Sciences, Adelaide & Meath Hospital</institution> Dublin 24,<country>Ireland</country></nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Coupier, I" sort="Coupier, I" uniqKey="Coupier I" first="I" last="Coupier">I. Coupier</name><affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Service de Génétique Médicale, Unité d'Oncogénétique, CHU Arnaud de Villeneuve</institution> Montpellier 34295,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff37"><institution>Unité d'Oncogénétique, CRLCC Val d'Aurelle</institution> Montpellier 34295,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giraud, S" sort="Giraud, S" uniqKey="Giraud S" first="S" last="Giraud">S. Giraud</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon / Centre Léon Bérard</institution> Lyon 69373,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Coulet, F" sort="Coulet, F" uniqKey="Coulet F" first="F" last="Coulet">F. Coulet</name><affiliation wicri:level="1"><nlm:aff id="aff38"><institution>Groupe Hospitalier Pitié-Salpêtriére, Assistance Publique-Hopitaux de Paris, Laboratoire d'Oncogénétique et Angiogénétique Moléculaire, Université Pierre et Marie Curie</institution> Paris 75651,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Colas, C" sort="Colas, C" uniqKey="Colas C" first="C" last="Colas">C. Colas</name><affiliation wicri:level="1"><nlm:aff id="aff38"><institution>Groupe Hospitalier Pitié-Salpêtriére, Assistance Publique-Hopitaux de Paris, Laboratoire d'Oncogénétique et Angiogénétique Moléculaire, Université Pierre et Marie Curie</institution> Paris 75651,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soubrier, F" sort="Soubrier, F" uniqKey="Soubrier F" first="F" last="Soubrier">F. Soubrier</name><affiliation wicri:level="1"><nlm:aff id="aff38"><institution>Groupe Hospitalier Pitié-Salpêtriére, Assistance Publique-Hopitaux de Paris, Laboratoire d'Oncogénétique et Angiogénétique Moléculaire, Université Pierre et Marie Curie</institution> Paris 75651,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rouleau, E" sort="Rouleau, E" uniqKey="Rouleau E" first="E" last="Rouleau">E. Rouleau</name><affiliation wicri:level="1"><nlm:aff id="aff39"><institution>INSERM U735 / Oncogenetics, Centre René Huguenin</institution> Saint-Cloud 92210,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bieche, I" sort="Bieche, I" uniqKey="Bieche I" first="I" last="Bièche">I. Bièche</name><affiliation wicri:level="1"><nlm:aff id="aff39"><institution>INSERM U735 / Oncogenetics, Centre René Huguenin</institution> Saint-Cloud 92210,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lidereau, R" sort="Lidereau, R" uniqKey="Lidereau R" first="R" last="Lidereau">R. Lidereau</name><affiliation wicri:level="1"><nlm:aff id="aff39"><institution>INSERM U735 / Oncogenetics, Centre René Huguenin</institution> Saint-Cloud 92210,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Demange, L" sort="Demange, L" uniqKey="Demange L" first="L" last="Demange">L. Demange</name><affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Epidémiologie Clinique, Oncogénétique, Centre René Huguenin</institution> Saint-Cloud 92210,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nogues, C" sort="Nogues, C" uniqKey="Nogues C" first="C" last="Nogues">C. Nogues</name><affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Epidémiologie Clinique, Oncogénétique, Centre René Huguenin</institution> Saint-Cloud 92210,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lynch, H T" sort="Lynch, H T" uniqKey="Lynch H" first="H T" last="Lynch">H T Lynch</name><affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Preventive Medicine, Creighton University</institution> Omaha, NE 68178,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmutzler, R K" sort="Schmutzler, R K" uniqKey="Schmutzler R" first="R K" last="Schmutzler">R K Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="aff43"><institution>Centre for hereditary Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne</institution> Cologne 50924,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Versmold, B" sort="Versmold, B" uniqKey="Versmold B" first="B" last="Versmold">B. Versmold</name><affiliation wicri:level="1"><nlm:aff id="aff43"><institution>Centre for hereditary Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne</institution> Cologne 50924,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Engel, C" sort="Engel, C" uniqKey="Engel C" first="C" last="Engel">C. Engel</name><affiliation wicri:level="1"><nlm:aff id="aff44"><institution>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig</institution> Leipzig 04103,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meindl, A" sort="Meindl, A" uniqKey="Meindl A" first="A" last="Meindl">A. Meindl</name><affiliation wicri:level="1"><nlm:aff id="aff45"><institution>Department of Obstetrics and Gynaecology, Technical University Munich</institution> Munich 80333,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arnold, N" sort="Arnold, N" uniqKey="Arnold N" first="N" last="Arnold">N. Arnold</name><affiliation wicri:level="1"><nlm:aff id="aff46"><institution>Department of Obstetrics and Gynaecology, University of Schleswig-Holstein</institution> Kiel 24105,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sutter, C" sort="Sutter, C" uniqKey="Sutter C" first="C" last="Sutter">C. Sutter</name><affiliation wicri:level="1"><nlm:aff id="aff47"><institution>Institute of Human Genetics, University of Heidelberg</institution> Heidelberg 69117,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deissler, H" sort="Deissler, H" uniqKey="Deissler H" first="H" last="Deissler">H. Deissler</name><affiliation wicri:level="1"><nlm:aff id="aff48"><institution>Department of Obstetrics and Gynaecology, University of Ulm</institution> Ulm 89069,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schaefer, D" sort="Schaefer, D" uniqKey="Schaefer D" first="D" last="Schaefer">D. Schaefer</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Institute of Human Genetics, University of Frankfurt</institution> Frankfurt 60325,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Froster, U G" sort="Froster, U G" uniqKey="Froster U" first="U G" last="Froster">U G Froster</name><affiliation wicri:level="1"><nlm:aff id="aff50"><institution>Institute of Human Genetics, University of Leipzig</institution> Leipzig 04103,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aittom Ki, K" sort="Aittom Ki, K" uniqKey="Aittom Ki K" first="K" last="Aittom Ki">K. Aittom Ki</name><affiliation wicri:level="1"><nlm:aff id="aff51"><institution>Department of Clinical Genetics, Helsinki University Central Hospital</institution> Helsinki, 00029 HUS,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nevanlinna, H" sort="Nevanlinna, H" uniqKey="Nevanlinna H" first="H" last="Nevanlinna">H. Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="aff52"><institution>Department of Obstetrics and Gynecology, Helsinki University Central Hospital</institution> Helsinki, 00029 HUS,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mcguffog, L" sort="Mcguffog, L" uniqKey="Mcguffog L" first="L" last="Mcguffog">L. Mcguffog</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</institution> Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Easton, D F" sort="Easton, D F" uniqKey="Easton D" first="D F" last="Easton">D F Easton</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</institution> Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chenevix Trench, G" sort="Chenevix Trench, G" uniqKey="Chenevix Trench G" first="G" last="Chenevix-Trench">G. Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Queensland Institute of Medical Research</institution> Brisbane QLD 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stoppa Lyonnet, D" sort="Stoppa Lyonnet, D" uniqKey="Stoppa Lyonnet D" first="D" last="Stoppa-Lyonnet">D. Stoppa-Lyonnet</name><affiliation wicri:level="1"><nlm:aff id="aff42"><institution>INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes</institution> Paris 75248,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19707196</idno><idno type="pmc">2768437</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2768437</idno><idno type="RBID">PMC:2768437</idno><idno type="doi">10.1038/sj.bjc.6605279</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">000028</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000028</idno><idno type="wicri:Area/Pmc/Curation">000028</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000028</idno><idno type="wicri:Area/Pmc/Checkpoint">002716</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002716</idno><idno type="wicri:Area/Ncbi/Merge">000635</idno><idno type="wicri:Area/Ncbi/Curation">000635</idno><idno type="wicri:Area/Ncbi/Checkpoint">000635</idno><idno type="wicri:Area/Main/Merge">008206</idno><idno type="wicri:Area/Main/Curation">007B53</idno><idno type="wicri:Area/Main/Exploration">007B53</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The <italic>TP53</italic> Arg72Pro and <italic>MDM2</italic> 309G>T polymorphisms are not associated with breast cancer risk in <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers</title><author><name sortKey="Sinilnikova, O M" sort="Sinilnikova, O M" uniqKey="Sinilnikova O" first="O M" last="Sinilnikova">O M Sinilnikova</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon / Centre Léon Bérard</institution> Lyon 69373,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Laboratoire de Génétique Moléculaire, Signalisation et Cancer, UMR5201 CNRS, Université de Lyon</institution> Lyon 69373,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Antoniou, A C" sort="Antoniou, A C" uniqKey="Antoniou A" first="A C" last="Antoniou">A C Antoniou</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</institution> Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Simard, J" sort="Simard, J" uniqKey="Simard J" first="J" last="Simard">J. Simard</name><affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Canada Research Chair in Oncogenetics, Cancer Genomics Laboratory, Centre Hospitalier Universitaire de Quebec and Laval University</institution> Quebec,<country>Canada</country> G1V 4G2</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Healey, S" sort="Healey, S" uniqKey="Healey S" first="S" last="Healey">S. Healey</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Queensland Institute of Medical Research</institution> Brisbane QLD 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Leone, M" sort="Leone, M" uniqKey="Leone M" first="M" last="Léoné">M. Léoné</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon / Centre Léon Bérard</institution> Lyon 69373,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sinnett, D" sort="Sinnett, D" uniqKey="Sinnett D" first="D" last="Sinnett">D. Sinnett</name><affiliation wicri:level="1"><nlm:aff id="aff6"><institution>Division of Hematology-Oncology, Research Center, CHU Sainte-Justine</institution> Montreal,<country>Canada</country> H3T 1C5</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff7"><institution>Department of Pediatrics, University of Montreal</institution> Montreal,<country>Canada</country> H3T 1C5</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Spurdle, A B" sort="Spurdle, A B" uniqKey="Spurdle A" first="A B" last="Spurdle">A B Spurdle</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Queensland Institute of Medical Research</institution> Brisbane QLD 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Beesley, J" sort="Beesley, J" uniqKey="Beesley J" first="J" last="Beesley">J. Beesley</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Queensland Institute of Medical Research</institution> Brisbane QLD 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chen, X" sort="Chen, X" uniqKey="Chen X" first="X" last="Chen">X. Chen</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Queensland Institute of Medical Research</institution> Brisbane QLD 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Greene, M H" sort="Greene, M H" uniqKey="Greene M" first="M H" last="Greene">M H Greene</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution> Rockville, MD 20852-7231,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Loud, J T" sort="Loud, J T" uniqKey="Loud J" first="J T" last="Loud">J T Loud</name><affiliation wicri:level="1"><nlm:aff id="aff9"><institution>Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute</institution> Rockville, MD 20852-7231,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lejbkowicz, F" sort="Lejbkowicz, F" uniqKey="Lejbkowicz F" first="F" last="Lejbkowicz">F. Lejbkowicz</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and Technion Faculty of Medicine</institution> Haifa 34362,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rennert, G" sort="Rennert, G" uniqKey="Rennert G" first="G" last="Rennert">G. Rennert</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and Technion Faculty of Medicine</institution> Haifa 34362,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dishon, S" sort="Dishon, S" uniqKey="Dishon S" first="S" last="Dishon">S. Dishon</name><affiliation wicri:level="1"><nlm:aff id="aff10"><institution>CHS National Cancer Control Center and Department of Community Medicine and Epidemiology, Carmel Medical Center and Technion Faculty of Medicine</institution> Haifa 34362,<country>Israel</country></nlm:aff><country xml:lang="fr">Israël</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Andrulis, I L" sort="Andrulis, I L" uniqKey="Andrulis I" first="I L" last="Andrulis">I L Andrulis</name><affiliation wicri:level="1"><nlm:aff id="aff11"><institution>Ontario Cancer Genetics Network, Cancer Care Ontario, Department of Molecular Genetics, University of Toronto</institution> Toronto, ON,<country>Canada</country> M5G 1X5</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff12"><institution>Samuel Lunenfeld Research Institute, Mount Sinai Hospital</institution> Toronto, ON,<country>Canada</country> M5G 1X5</nlm:aff><country xml:lang="fr">Canada</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Domchek, S M" sort="Domchek, S M" uniqKey="Domchek S" first="S M" last="Domchek">S M Domchek</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Department of Medicine, Abramson Cancer Center, University of Pennsylvania School of Medicine</institution> Philadelphia, PA 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nathanson, K L" sort="Nathanson, K L" uniqKey="Nathanson K" first="K L" last="Nathanson">K L Nathanson</name><affiliation wicri:level="1"><nlm:aff id="aff13"><institution>Department of Medicine, Abramson Cancer Center, University of Pennsylvania School of Medicine</institution> Philadelphia, PA 19104,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Manoukian, S" sort="Manoukian, S" uniqKey="Manoukian S" first="S" last="Manoukian">S. Manoukian</name><affiliation wicri:level="1"><nlm:aff id="aff14"><institution>Unit of Medical Genetics, Fondazione IRCCS Istituto Nazionale Tumori</institution> Milano,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Radice, P" sort="Radice, P" uniqKey="Radice P" first="P" last="Radice">P. Radice</name><affiliation wicri:level="1"><nlm:aff id="aff15"><institution>Department of Experimental Oncology, Fondazione IRCCS Istituto Nazionale Tumori</institution> Milano 20133,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff16"><institution>IFOM, Fondazione Istituto FIRC di Oncologia Molecolare</institution> Milano 20139,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Konstantopoulou, I" sort="Konstantopoulou, I" uniqKey="Konstantopoulou I" first="I" last="Konstantopoulou">I. Konstantopoulou</name><affiliation wicri:level="1"><nlm:aff id="aff17"><institution>Molecular Diagnostics Laboratory, IRRP, NCSR ‘Demokritos'</institution> 15310 Ag. Paraskevi, Athens,<country>Greece</country></nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Blanco, I" sort="Blanco, I" uniqKey="Blanco I" first="I" last="Blanco">I. Blanco</name><affiliation wicri:level="1"><nlm:aff id="aff18"><institution>Cancer Genetic Counseling Program, Institut Català d'Oncologia</institution> Barcelona 08907,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Laborde, A L" sort="Laborde, A L" uniqKey="Laborde A" first="A L" last="Laborde">A L Laborde</name><affiliation wicri:level="1"><nlm:aff id="aff19"><institution>Servicio de Genética, Hospital de la Santa Creu i Sant Pau</institution> Barcelona 08025,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Duran, M" sort="Duran, M" uniqKey="Duran M" first="M" last="Durán">M. Durán</name><affiliation wicri:level="1"><nlm:aff id="aff20"><institution>Laboratorio de Genética del Cáncer, Instituto de Biología y Genética Molecular, Universidad de Valladolid</institution> Valladolid 47002,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Osorio, A" sort="Osorio, A" uniqKey="Osorio A" first="A" last="Osorio">A. Osorio</name><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)</institution> Madrid 28029,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Benitez, J" sort="Benitez, J" uniqKey="Benitez J" first="J" last="Benitez">J. Benitez</name><affiliation wicri:level="1"><nlm:aff id="aff21"><institution>Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO)</institution> Madrid 28029,<country>Spain</country></nlm:aff><country xml:lang="fr">Espagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hamann, U" sort="Hamann, U" uniqKey="Hamann U" first="U" last="Hamann">U. Hamann</name><affiliation wicri:level="1"><nlm:aff id="aff22"><institution>Deutsches Krebsforschungszentrum (DKFZ), Molecular Genetics of Breast Cancer</institution> Heidelberg 69120,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hogervorst, F B L" sort="Hogervorst, F B L" uniqKey="Hogervorst F" first="F B L" last="Hogervorst">F B L. Hogervorst</name><affiliation wicri:level="1"><nlm:aff id="aff23"><institution>Department of Pathology and the Family Cancer Clinic, Netherlands Cancer Institute</institution> Amsterdam 1066 CX,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Van Os, T A M" sort="Van Os, T A M" uniqKey="Van Os T" first="T A M" last="Van Os">T A M. Van Os</name><affiliation wicri:level="1"><nlm:aff id="aff24"><institution>Department of Clinical Genetics, Amsterdam University Medical Centre</institution> Amsterdam 1105 AZ,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Gille, H J P" sort="Gille, H J P" uniqKey="Gille H" first="H J P" last="Gille">H J P. Gille</name><affiliation wicri:level="1"><nlm:aff id="aff25"><institution>Department of Clinical Molecular Genetics, Free University Medical Centre</institution> Amsterdam 1081 HV,<country>The Netherlands</country></nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Peock, S" sort="Peock, S" uniqKey="Peock S" first="S" last="Peock">S. Peock</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</institution> Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cook, M" sort="Cook, M" uniqKey="Cook M" first="M" last="Cook">M. Cook</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</institution> Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Luccarini, C" sort="Luccarini, C" uniqKey="Luccarini C" first="C" last="Luccarini">C. Luccarini</name><affiliation wicri:level="1"><nlm:aff id="aff26"><institution>Department of Oncology, University of Cambridge</institution> Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Evans, D G" sort="Evans, D G" uniqKey="Evans D" first="D G" last="Evans">D G Evans</name><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust</institution> Manchester M13 OJH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lalloo, F" sort="Lalloo, F" uniqKey="Lalloo F" first="F" last="Lalloo">F. Lalloo</name><affiliation wicri:level="1"><nlm:aff id="aff27"><institution>Manchester Academic Health Sciences Centre, Central Manchester University Hospitals NHS Foundation Trust</institution> Manchester M13 OJH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Eeles, R" sort="Eeles, R" uniqKey="Eeles R" first="R" last="Eeles">R. Eeles</name><affiliation wicri:level="1"><nlm:aff id="aff28"><institution>Translational Cancer Genetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust</institution> Sutton, Surrey SM2 5NG,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pichert, G" sort="Pichert, G" uniqKey="Pichert G" first="G" last="Pichert">G. Pichert</name><affiliation wicri:level="1"><nlm:aff id="aff29"><institution>Clinical Genetics, Guy's Hospital</institution> London SE1 9RT,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Davidson, R" sort="Davidson, R" uniqKey="Davidson R" first="R" last="Davidson">R. Davidson</name><affiliation wicri:level="1"><nlm:aff id="aff30"><institution>Ferguson-Smith Centre for Clinical Genetics</institution> Glasgow G3 8SJ,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cole, T" sort="Cole, T" uniqKey="Cole T" first="T" last="Cole">T. Cole</name><affiliation wicri:level="1"><nlm:aff id="aff31"><institution>West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust</institution> Edgbaston, Birmingham B15 2TG,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cook, J" sort="Cook, J" uniqKey="Cook J" first="J" last="Cook">J. Cook</name><affiliation wicri:level="1"><nlm:aff id="aff32"><institution>Sheffield Clinical Genetics Service, Sheffield Children's Hospital</institution> Sheffield S10 2TH,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Paterson, J" sort="Paterson, J" uniqKey="Paterson J" first="J" last="Paterson">J. Paterson</name><affiliation wicri:level="1"><nlm:aff id="aff33"><institution>Department of Clinical Genetics, East Anglian Regional Genetics Service, Addenbrookes Hospital</institution> Cambridge CB2 8QE,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Brewer, C" sort="Brewer, C" uniqKey="Brewer C" first="C" last="Brewer">C. Brewer</name><affiliation wicri:level="1"><nlm:aff id="aff34"><institution>Department of Clinical Genetics, Royal Devon & Exeter Hospital</institution> Exeter EX2 5DW,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hughes, D J" sort="Hughes, D J" uniqKey="Hughes D" first="D J" last="Hughes">D J Hughes</name><affiliation wicri:level="1"><nlm:aff id="aff35"><institution>Department of Clinical Medicine, Trinity College Centre for Health Sciences, Adelaide & Meath Hospital</institution> Dublin 24,<country>Ireland</country></nlm:aff><country xml:lang="fr">Irlande (pays)</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Coupier, I" sort="Coupier, I" uniqKey="Coupier I" first="I" last="Coupier">I. Coupier</name><affiliation wicri:level="1"><nlm:aff id="aff36"><institution>Service de Génétique Médicale, Unité d'Oncogénétique, CHU Arnaud de Villeneuve</institution> Montpellier 34295,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff37"><institution>Unité d'Oncogénétique, CRLCC Val d'Aurelle</institution> Montpellier 34295,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Giraud, S" sort="Giraud, S" uniqKey="Giraud S" first="S" last="Giraud">S. Giraud</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Unité Mixte de Génétique Constitutionnelle des Cancers Fréquents, Hospices Civils de Lyon / Centre Léon Bérard</institution> Lyon 69373,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Coulet, F" sort="Coulet, F" uniqKey="Coulet F" first="F" last="Coulet">F. Coulet</name><affiliation wicri:level="1"><nlm:aff id="aff38"><institution>Groupe Hospitalier Pitié-Salpêtriére, Assistance Publique-Hopitaux de Paris, Laboratoire d'Oncogénétique et Angiogénétique Moléculaire, Université Pierre et Marie Curie</institution> Paris 75651,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Colas, C" sort="Colas, C" uniqKey="Colas C" first="C" last="Colas">C. Colas</name><affiliation wicri:level="1"><nlm:aff id="aff38"><institution>Groupe Hospitalier Pitié-Salpêtriére, Assistance Publique-Hopitaux de Paris, Laboratoire d'Oncogénétique et Angiogénétique Moléculaire, Université Pierre et Marie Curie</institution> Paris 75651,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Soubrier, F" sort="Soubrier, F" uniqKey="Soubrier F" first="F" last="Soubrier">F. Soubrier</name><affiliation wicri:level="1"><nlm:aff id="aff38"><institution>Groupe Hospitalier Pitié-Salpêtriére, Assistance Publique-Hopitaux de Paris, Laboratoire d'Oncogénétique et Angiogénétique Moléculaire, Université Pierre et Marie Curie</institution> Paris 75651,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rouleau, E" sort="Rouleau, E" uniqKey="Rouleau E" first="E" last="Rouleau">E. Rouleau</name><affiliation wicri:level="1"><nlm:aff id="aff39"><institution>INSERM U735 / Oncogenetics, Centre René Huguenin</institution> Saint-Cloud 92210,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bieche, I" sort="Bieche, I" uniqKey="Bieche I" first="I" last="Bièche">I. Bièche</name><affiliation wicri:level="1"><nlm:aff id="aff39"><institution>INSERM U735 / Oncogenetics, Centre René Huguenin</institution> Saint-Cloud 92210,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lidereau, R" sort="Lidereau, R" uniqKey="Lidereau R" first="R" last="Lidereau">R. Lidereau</name><affiliation wicri:level="1"><nlm:aff id="aff39"><institution>INSERM U735 / Oncogenetics, Centre René Huguenin</institution> Saint-Cloud 92210,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Demange, L" sort="Demange, L" uniqKey="Demange L" first="L" last="Demange">L. Demange</name><affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Epidémiologie Clinique, Oncogénétique, Centre René Huguenin</institution> Saint-Cloud 92210,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nogues, C" sort="Nogues, C" uniqKey="Nogues C" first="C" last="Nogues">C. Nogues</name><affiliation wicri:level="1"><nlm:aff id="aff40"><institution>Epidémiologie Clinique, Oncogénétique, Centre René Huguenin</institution> Saint-Cloud 92210,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lynch, H T" sort="Lynch, H T" uniqKey="Lynch H" first="H T" last="Lynch">H T Lynch</name><affiliation wicri:level="1"><nlm:aff id="aff41"><institution>Department of Preventive Medicine, Creighton University</institution> Omaha, NE 68178,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schmutzler, R K" sort="Schmutzler, R K" uniqKey="Schmutzler R" first="R K" last="Schmutzler">R K Schmutzler</name><affiliation wicri:level="1"><nlm:aff id="aff43"><institution>Centre for hereditary Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne</institution> Cologne 50924,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Versmold, B" sort="Versmold, B" uniqKey="Versmold B" first="B" last="Versmold">B. Versmold</name><affiliation wicri:level="1"><nlm:aff id="aff43"><institution>Centre for hereditary Breast and Ovarian Cancer, Department of Obstetrics and Gynaecology, University of Cologne</institution> Cologne 50924,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Engel, C" sort="Engel, C" uniqKey="Engel C" first="C" last="Engel">C. Engel</name><affiliation wicri:level="1"><nlm:aff id="aff44"><institution>Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig</institution> Leipzig 04103,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Meindl, A" sort="Meindl, A" uniqKey="Meindl A" first="A" last="Meindl">A. Meindl</name><affiliation wicri:level="1"><nlm:aff id="aff45"><institution>Department of Obstetrics and Gynaecology, Technical University Munich</institution> Munich 80333,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Arnold, N" sort="Arnold, N" uniqKey="Arnold N" first="N" last="Arnold">N. Arnold</name><affiliation wicri:level="1"><nlm:aff id="aff46"><institution>Department of Obstetrics and Gynaecology, University of Schleswig-Holstein</institution> Kiel 24105,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sutter, C" sort="Sutter, C" uniqKey="Sutter C" first="C" last="Sutter">C. Sutter</name><affiliation wicri:level="1"><nlm:aff id="aff47"><institution>Institute of Human Genetics, University of Heidelberg</institution> Heidelberg 69117,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Deissler, H" sort="Deissler, H" uniqKey="Deissler H" first="H" last="Deissler">H. Deissler</name><affiliation wicri:level="1"><nlm:aff id="aff48"><institution>Department of Obstetrics and Gynaecology, University of Ulm</institution> Ulm 89069,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schaefer, D" sort="Schaefer, D" uniqKey="Schaefer D" first="D" last="Schaefer">D. Schaefer</name><affiliation wicri:level="1"><nlm:aff id="aff49"><institution>Institute of Human Genetics, University of Frankfurt</institution> Frankfurt 60325,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Froster, U G" sort="Froster, U G" uniqKey="Froster U" first="U G" last="Froster">U G Froster</name><affiliation wicri:level="1"><nlm:aff id="aff50"><institution>Institute of Human Genetics, University of Leipzig</institution> Leipzig 04103,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Aittom Ki, K" sort="Aittom Ki, K" uniqKey="Aittom Ki K" first="K" last="Aittom Ki">K. Aittom Ki</name><affiliation wicri:level="1"><nlm:aff id="aff51"><institution>Department of Clinical Genetics, Helsinki University Central Hospital</institution> Helsinki, 00029 HUS,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Nevanlinna, H" sort="Nevanlinna, H" uniqKey="Nevanlinna H" first="H" last="Nevanlinna">H. Nevanlinna</name><affiliation wicri:level="1"><nlm:aff id="aff52"><institution>Department of Obstetrics and Gynecology, Helsinki University Central Hospital</institution> Helsinki, 00029 HUS,<country>Finland</country></nlm:aff><country xml:lang="fr">Finlande</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mcguffog, L" sort="Mcguffog, L" uniqKey="Mcguffog L" first="L" last="Mcguffog">L. Mcguffog</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</institution> Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Easton, D F" sort="Easton, D F" uniqKey="Easton D" first="D F" last="Easton">D F Easton</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Cancer Research UK, Genetic Epidemiology Unit, Department of Public Health and Primary Care, University of Cambridge</institution> Cambridge CB1 8RN,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chenevix Trench, G" sort="Chenevix Trench, G" uniqKey="Chenevix Trench G" first="G" last="Chenevix-Trench">G. Chenevix-Trench</name><affiliation wicri:level="1"><nlm:aff id="aff5"><institution>Queensland Institute of Medical Research</institution> Brisbane QLD 4029,<country>Australia</country></nlm:aff><country xml:lang="fr">Australie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Stoppa Lyonnet, D" sort="Stoppa Lyonnet, D" uniqKey="Stoppa Lyonnet D" first="D" last="Stoppa-Lyonnet">D. Stoppa-Lyonnet</name><affiliation wicri:level="1"><nlm:aff id="aff42"><institution>INSERM U509, Service de Génétique Oncologique, Institut Curie, Université Paris-Descartes</institution> Paris 75248,<country>France</country></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>The <italic>TP53</italic> pathway, in which <italic>TP53</italic> and its negative regulator <italic>MDM2</italic> are the central elements, has an important role in carcinogenesis, particularly in <italic>BRCA1-</italic> and <italic>BRCA2-</italic>mediated carcinogenesis. A single nucleotide polymorphism (SNP) in the promoter region of <italic>MDM2</italic> (309T>G, rs2279744) and a coding SNP of <italic>TP53</italic> (Arg72Pro, rs1042522) have been shown to be of functional significance.</p></sec><sec><title>Methods:</title><p>To investigate whether these SNPs modify breast cancer risk for <italic>BRCA1</italic> and <italic>BRCA2</italic> mutation carriers, we pooled genotype data on the <italic>TP53</italic> Arg72Pro SNP in 7011 mutation carriers and on the <italic>MDM2</italic> 309T>G SNP in 2222 mutation carriers from the Consortium of Investigators of Modifiers of <italic>BRCA1/2</italic> (CIMBA). Data were analysed using a Cox proportional hazards model within a retrospective likelihood framework.</p></sec><sec><title>Results:</title><p>No association was found between these SNPs and breast cancer risk for <italic>BRCA1</italic> (<italic>TP53</italic>: per-allele hazard ratio (HR)=1.01, 95% confidence interval (CI): 0.93–1.10, <italic>P</italic><sub>trend</sub>=0.77; <italic>MDM2</italic>: HR=0.96, 95%CI: 0.84–1.09, <italic>P</italic><sub>trend</sub>=0.54) or for <italic>BRCA2</italic> mutation carriers (<italic>TP53</italic>: HR=0.99, 95%CI: 0.87–1.12, <italic>P</italic><sub>trend</sub>=0.83; <italic>MDM2</italic>: HR=0.98, 95%CI: 0.80–1.21, <italic>P</italic><sub>trend</sub>=0.88). We also evaluated the potential combined effects of both SNPs on breast cancer risk, however, none of their combined genotypes showed any evidence of association.</p></sec><sec><title>Conclusion:</title><p>There was no evidence that <italic>TP53</italic> Arg72Pro or <italic>MDM2</italic> 309T>G, either singly or in combination, influence breast cancer risk in <italic>BRCA1</italic> or <italic>BRCA2</italic> mutation carriers.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Espagne</li><li>Finlande</li><li>France</li><li>Grèce</li><li>Irlande (pays)</li><li>Israël</li><li>Italie</li><li>Pays-Bas</li><li>Royaume-Uni</li><li>États-Unis</li></country></list><tree><country name="France"><noRegion><name sortKey="Sinilnikova, O M" sort="Sinilnikova, O M" uniqKey="Sinilnikova O" first="O M" last="Sinilnikova">O M Sinilnikova</name></noRegion><name sortKey="Bieche, I" sort="Bieche, I" uniqKey="Bieche I" first="I" last="Bièche">I. Bièche</name><name sortKey="Colas, C" sort="Colas, C" uniqKey="Colas C" first="C" last="Colas">C. Colas</name><name sortKey="Coulet, F" sort="Coulet, F" uniqKey="Coulet F" first="F" last="Coulet">F. Coulet</name><name sortKey="Coupier, I" sort="Coupier, I" uniqKey="Coupier I" first="I" last="Coupier">I. Coupier</name><name sortKey="Coupier, I" sort="Coupier, I" uniqKey="Coupier I" first="I" last="Coupier">I. Coupier</name><name sortKey="Demange, L" sort="Demange, L" uniqKey="Demange L" first="L" last="Demange">L. Demange</name><name sortKey="Giraud, S" sort="Giraud, S" uniqKey="Giraud S" first="S" last="Giraud">S. Giraud</name><name sortKey="Leone, M" sort="Leone, M" uniqKey="Leone M" first="M" last="Léoné">M. Léoné</name><name sortKey="Lidereau, R" sort="Lidereau, R" uniqKey="Lidereau R" first="R" last="Lidereau">R. Lidereau</name><name sortKey="Nogues, C" sort="Nogues, C" uniqKey="Nogues C" first="C" last="Nogues">C. Nogues</name><name sortKey="Rouleau, E" sort="Rouleau, E" uniqKey="Rouleau E" first="E" last="Rouleau">E. Rouleau</name><name sortKey="Sinilnikova, O M" sort="Sinilnikova, O M" uniqKey="Sinilnikova O" first="O M" last="Sinilnikova">O M Sinilnikova</name><name sortKey="Soubrier, F" sort="Soubrier, F" uniqKey="Soubrier F" first="F" last="Soubrier">F. Soubrier</name><name sortKey="Stoppa Lyonnet, D" sort="Stoppa Lyonnet, D" uniqKey="Stoppa Lyonnet D" first="D" last="Stoppa-Lyonnet">D. Stoppa-Lyonnet</name></country><country name="Royaume-Uni"><noRegion><name sortKey="Antoniou, A C" sort="Antoniou, A C" uniqKey="Antoniou A" first="A C" last="Antoniou">A C Antoniou</name></noRegion><name sortKey="Brewer, C" sort="Brewer, C" uniqKey="Brewer C" first="C" last="Brewer">C. Brewer</name><name sortKey="Cole, T" sort="Cole, T" uniqKey="Cole T" first="T" last="Cole">T. Cole</name><name sortKey="Cook, J" sort="Cook, J" uniqKey="Cook J" first="J" last="Cook">J. Cook</name><name sortKey="Cook, M" sort="Cook, M" uniqKey="Cook M" first="M" last="Cook">M. Cook</name><name sortKey="Davidson, R" sort="Davidson, R" uniqKey="Davidson R" first="R" last="Davidson">R. Davidson</name><name sortKey="Easton, D F" sort="Easton, D F" uniqKey="Easton D" first="D F" last="Easton">D F Easton</name><name sortKey="Eeles, R" sort="Eeles, R" uniqKey="Eeles R" first="R" last="Eeles">R. Eeles</name><name sortKey="Evans, D G" sort="Evans, D G" uniqKey="Evans D" first="D G" last="Evans">D G Evans</name><name sortKey="Lalloo, F" sort="Lalloo, F" uniqKey="Lalloo F" first="F" last="Lalloo">F. Lalloo</name><name sortKey="Luccarini, C" sort="Luccarini, C" uniqKey="Luccarini C" first="C" last="Luccarini">C. Luccarini</name><name sortKey="Mcguffog, L" sort="Mcguffog, L" uniqKey="Mcguffog L" first="L" last="Mcguffog">L. Mcguffog</name><name sortKey="Paterson, J" sort="Paterson, J" uniqKey="Paterson J" first="J" last="Paterson">J. Paterson</name><name sortKey="Peock, S" sort="Peock, S" uniqKey="Peock S" first="S" last="Peock">S. Peock</name><name sortKey="Pichert, G" sort="Pichert, G" uniqKey="Pichert G" first="G" last="Pichert">G. Pichert</name></country><country name="Canada"><noRegion><name sortKey="Simard, J" sort="Simard, J" uniqKey="Simard J" first="J" last="Simard">J. Simard</name></noRegion><name sortKey="Andrulis, I L" sort="Andrulis, I L" uniqKey="Andrulis I" first="I L" last="Andrulis">I L Andrulis</name><name sortKey="Andrulis, I L" sort="Andrulis, I L" uniqKey="Andrulis I" first="I L" last="Andrulis">I L Andrulis</name><name sortKey="Sinnett, D" sort="Sinnett, D" uniqKey="Sinnett D" first="D" last="Sinnett">D. Sinnett</name><name sortKey="Sinnett, D" sort="Sinnett, D" uniqKey="Sinnett D" first="D" last="Sinnett">D. Sinnett</name></country><country name="Australie"><noRegion><name sortKey="Healey, S" sort="Healey, S" uniqKey="Healey S" first="S" last="Healey">S. 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Chenevix-Trench</name><name sortKey="Spurdle, A B" sort="Spurdle, A B" uniqKey="Spurdle A" first="A B" last="Spurdle">A B Spurdle</name></country><country name="États-Unis"><noRegion><name sortKey="Greene, M H" sort="Greene, M H" uniqKey="Greene M" first="M H" last="Greene">M H Greene</name></noRegion><name sortKey="Domchek, S M" sort="Domchek, S M" uniqKey="Domchek S" first="S M" last="Domchek">S M Domchek</name><name sortKey="Loud, J T" sort="Loud, J T" uniqKey="Loud J" first="J T" last="Loud">J T Loud</name><name sortKey="Lynch, H T" sort="Lynch, H T" uniqKey="Lynch H" first="H T" last="Lynch">H T Lynch</name><name sortKey="Nathanson, K L" sort="Nathanson, K L" uniqKey="Nathanson K" first="K L" last="Nathanson">K L Nathanson</name></country><country name="Israël"><noRegion><name sortKey="Lejbkowicz, F" sort="Lejbkowicz, F" uniqKey="Lejbkowicz F" first="F" last="Lejbkowicz">F. Lejbkowicz</name></noRegion><name sortKey="Dishon, S" sort="Dishon, S" uniqKey="Dishon S" first="S" last="Dishon">S. Dishon</name><name sortKey="Rennert, G" sort="Rennert, G" uniqKey="Rennert G" first="G" last="Rennert">G. Rennert</name></country><country name="Italie"><noRegion><name sortKey="Manoukian, S" sort="Manoukian, S" uniqKey="Manoukian S" first="S" last="Manoukian">S. Manoukian</name></noRegion><name sortKey="Radice, P" sort="Radice, P" uniqKey="Radice P" first="P" last="Radice">P. Radice</name><name sortKey="Radice, P" sort="Radice, P" uniqKey="Radice P" first="P" last="Radice">P. Radice</name></country><country name="Grèce"><noRegion><name sortKey="Konstantopoulou, I" sort="Konstantopoulou, I" uniqKey="Konstantopoulou I" first="I" last="Konstantopoulou">I. Konstantopoulou</name></noRegion></country><country name="Espagne"><noRegion><name sortKey="Blanco, I" sort="Blanco, I" uniqKey="Blanco I" first="I" last="Blanco">I. Blanco</name></noRegion><name sortKey="Benitez, J" sort="Benitez, J" uniqKey="Benitez J" first="J" last="Benitez">J. Benitez</name><name sortKey="Duran, M" sort="Duran, M" uniqKey="Duran M" first="M" last="Durán">M. Durán</name><name sortKey="Laborde, A L" sort="Laborde, A L" uniqKey="Laborde A" first="A L" last="Laborde">A L Laborde</name><name sortKey="Osorio, A" sort="Osorio, A" uniqKey="Osorio A" first="A" last="Osorio">A. Osorio</name></country><country name="Allemagne"><noRegion><name sortKey="Hamann, U" sort="Hamann, U" uniqKey="Hamann U" first="U" last="Hamann">U. Hamann</name></noRegion><name sortKey="Arnold, N" sort="Arnold, N" uniqKey="Arnold N" first="N" last="Arnold">N. Arnold</name><name sortKey="Deissler, H" sort="Deissler, H" uniqKey="Deissler H" first="H" last="Deissler">H. Deissler</name><name sortKey="Engel, C" sort="Engel, C" uniqKey="Engel C" first="C" last="Engel">C. Engel</name><name sortKey="Froster, U G" sort="Froster, U G" uniqKey="Froster U" first="U G" last="Froster">U G Froster</name><name sortKey="Meindl, A" sort="Meindl, A" uniqKey="Meindl A" first="A" last="Meindl">A. Meindl</name><name sortKey="Schaefer, D" sort="Schaefer, D" uniqKey="Schaefer D" first="D" last="Schaefer">D. Schaefer</name><name sortKey="Schmutzler, R K" sort="Schmutzler, R K" uniqKey="Schmutzler R" first="R K" last="Schmutzler">R K Schmutzler</name><name sortKey="Sutter, C" sort="Sutter, C" uniqKey="Sutter C" first="C" last="Sutter">C. Sutter</name><name sortKey="Versmold, B" sort="Versmold, B" uniqKey="Versmold B" first="B" last="Versmold">B. Versmold</name></country><country name="Pays-Bas"><noRegion><name sortKey="Hogervorst, F B L" sort="Hogervorst, F B L" uniqKey="Hogervorst F" first="F B L" last="Hogervorst">F B L. Hogervorst</name></noRegion><name sortKey="Gille, H J P" sort="Gille, H J P" uniqKey="Gille H" first="H J P" last="Gille">H J P. Gille</name><name sortKey="Van Os, T A M" sort="Van Os, T A M" uniqKey="Van Os T" first="T A M" last="Van Os">T A M. Van Os</name></country><country name="Irlande (pays)"><noRegion><name sortKey="Hughes, D J" sort="Hughes, D J" uniqKey="Hughes D" first="D J" last="Hughes">D J Hughes</name></noRegion></country><country name="Finlande"><noRegion><name sortKey="Aittom Ki, K" sort="Aittom Ki, K" uniqKey="Aittom Ki K" first="K" last="Aittom Ki">K. Aittom Ki</name></noRegion><name sortKey="Nevanlinna, H" sort="Nevanlinna, H" uniqKey="Nevanlinna H" first="H" last="Nevanlinna">H. Nevanlinna</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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